Practice English Speaking&Listening with: Engineering biology to make materials for energy devices | Angela Belcher | TEDxCaltech

Difficulty: 0

Transcriber: Camille Martínez Reviewer: Ivana Korom

I'm so excited to be here to celebrate this really special event.

I thought I'd talk a little bit about how nature makes materials.

I brought along with me an abalone shell.

This abalone shell is a biocomposite material

that's 98 percent by mass calcium carbonate

and two percent by mass protein.

Yet, it's 3,000 times tougher than its geological counterpart.

And a lot of people might use structures like abalone shells,

like chalk.

I've been fascinated by how nature makes materials,

and there's a lot of secrets to how they do such an exquisite job.

Part of it is that these materials are macroscopic in structure,

but they're formed at the nano scale.

They're formed at the nano scale,

and they use proteins that are coded by the genetic level

that allow them to build these really exquisite structures.

So something I think is very fascinating is:

What if you could give life to non-living structures,

like batteries and like solar cells?

What if they had some of the same capabilities

that an abalone shell did,

in terms of being able to build really exquisite structures

at room temperature and room pressure,

using nontoxic chemicals

and adding no toxic materials back into the environment?

So that's kind of the vision that I've been thinking about.

And so what if you could grow a battery in a Petri dish?

Or what if you could give genetic information to a battery

so that it could actually become better as a function of time, and do so

in an environmentally friendly way?

And so, going back to this abalone shell,

besides being nanostructured, one thing that's fascinating is,

when a male and female abalone get together,

they pass on the genetic information that says,

"This is how to build an exquisite material.

Here's how to do it at room temperature and pressure,

using nontoxic materials."

Same with diatoms, which are shown right here,

which are glasseous structures.

Every time the diatoms replicate,

they give the genetic information that says,

"Here's how to build glass in the ocean that's perfectly nanostructured."

And you can do it the same, over and over again."

So what if you could do the same thing with a solar cell or a battery?

I like to say my favorite biomaterial is my four year old.

But anyone who's ever had or knows small children knows,

they're incredibly complex organisms.

If you wanted to convince them to do something they don't want to do,

it's very difficult.

So when we think about future technologies,

we actually think of using bacteria and viruses...

Simple organisms.

Can you convince them to work with a new toolbox,

so they can build a structure that will be important to me?

Also, when we think about future technologies,

we start with the beginning of Earth.

Basically, it took a billion years to have life on Earth.

And very rapidly, they became multi-cellular,

they could replicate, they could use photosynthesis

as a way of getting their energy source.

But it wasn't until about 500 million years ago...

During the Cambrian geologic time period...

That organisms in the ocean started making hard materials.

Before that, they were all soft, fluffy structures.

It was during this time that there was increased calcium,

iron and silicon in the environment,

and organisms learned how to make hard materials.

So that's what I would like to be able to do,

convince biology to work with the rest of the periodic table.

Now, if you look at biology,

there's many structures like DNA, antibodies, proteins and ribosomes

you've heard about,

that are nanostructured...

Nature already gives us really exquisite structures on the nano scale.

What if we could harness them

and convince them to not be an antibody that does something like HIV,

which was an incredibly interesting talk earlier,

but what if we could convince them to build a solar cell for us?

Here are some examples.

Natural shells, natural biological materials.

The abalone shell here.

If you fracture it, you can look at the fact that it's nanostructured.

There's diatoms made out of SiO2,

and there are magnetotactic bacteria

that make small, single-domain magnets used for navigation.

What all these have in common

is these materials are structured at the nano scale,

and they have a DNA sequence that codes for a protein sequence

that gives them the blueprint

to be able to build these really wonderful structures.

Now, going back to the abalone shell,

the abalone makes this shell by having these proteins.

These proteins are very negatively charged.

They can pull calcium out of the environment,

and put down a layer of calcium and then carbonate, calcium and carbonate.

It has the chemical sequences of amino acids which says,

"This is how to build the structure.

Here's the DNA sequence, here's the protein sequence

in order to do it."

So an interesting idea is,

what if you could take any material you wanted,

or any element on the periodic table,

and find its corresponding DNA sequence,

then code it for a corresponding protein sequence to build a structure,

but not build an abalone shell...

Build something that nature has never had the opportunity to work with yet.

And so here's the periodic table.

I absolutely love the periodic table.

Every year for the incoming freshman class at MIT,

I have a periodic table made that says,

"Welcome to MIT. Now you're in your element."


And you flip it over, and it's the amino acids

with the pH at which they have different charges.

And so I give this out to thousands of people.

And I know it says MIT and this is Caltech,

but I have a couple extra if people want it.

I was really fortunate to have President Obama visit my lab this year

on his visit to MIT,

and I really wanted to give him a periodic table.

So I stayed up at night and talked to my husband,

"How do I give President Obama a periodic table?

What if he says, 'Oh, I already have one, '

or, 'I've already memorized it?'"


So he came to visit my lab and looked around... it was a great visit.

And then afterward, I said,

"Sir, I want to give you the periodic table,

in case you're ever in a bind and need to calculate molecular weight."


I thought "molecular weight" sounded much less nerdy than "molar mass."


And he looked at it and said,

"Thank you. I'll look at it periodically."



Later in a lecture that he gave on clean energy,

he pulled it out and said,

"And people at MIT, they give out periodic tables." So...

So basically what I didn't tell you

is that about 500 million years ago, the organisms started making materials,

but it took them about 50 million years to get good at it...

50 million years to learn how to perfect how to make that abalone shell.

And that's a hard sell to a graduate student:

"I have this great project... 50 million years ..."

So we had to develop a way of trying to do this more rapidly.

And so we use a nontoxic virus called M13 bacteriophage,

whose job is to infect bacteria.

Well, it has a simple DNA structure

that you can go in and cut and paste additional DNA sequences into it,

and by doing that, it allows the virus to express random protein sequences.

This is pretty easy biotechnology,

and you could basically do this a billion times.

So you can have a billion different viruses

that are all genetically identical,

but they differ from each other based on their tips,

on one sequence,

that codes for one protein.

Now if you take all billion viruses, and put them in one drop of liquid,

you can force them to interact with anything you want

on the periodic table.

And through a process of selection evolution,

you can pull one of a billion that does something you'd like it to do,

like grow a battery or a solar cell.

Basically, viruses can't replicate themselves; they need a host.

Once you find that one out of a billion,

you infect it into a bacteria, and make millions and billions of copies

of that particular sequence.

The other thing that's beautiful about biology

is that biology gives you really exquisite structures

with nice link scales.

These viruses are long and skinny,

and we can get them to express the ability

to grow something like semiconductors

or materials for batteries.

Now, this is a high-powered battery that we grew in my lab.

We engineered a virus to pick up carbon nanotubes you heard about earlier.

One part of the virus grabs a carbon nanotube,

the other part of the virus has a sequence

that can grow an electrode material for a battery,

and then it wires itself to the current collector.

And so through a process of selection evolution,

we went from being able to have a virus that made a crummy battery

to a virus that made a good battery

to a virus that made a record-breaking, high-powered battery

that's all made at room temperature, basically at the benchtop.

That battery went to the White House for a press conference,

and I brought it here.

You can see it in this case that's lighting this LED.

Now if we could scale this,

you could actually use it to run your Prius,

which is kind of my dream... To be able to drive a virus-powered car.


But basically you can pull one out of a billion,

and make lots of amplifications to it.

Basically, you make an amplification in the lab,

and then you get it to self-assemble into a structure like a battery.

We're able to do this also with catalysis.

This is the example of a photocatalytic splitting of water.

And what we've been able to do is engineer a virus

to basically take dye-absorbing molecules

and line them up on the surface of the virus

so it acts as an antenna,

and you get an energy transfer across the virus.

And then we give it a second gene to grow an inorganic material

that can be used to split water into oxygen and hydrogen,

that can be used for clean fuels.

I brought an example of that with me today.

My students promised me it would work.

These are virus-assembled nanowires.

When you shine light on them, you can see them bubbling.

In this case, you're seeing oxygen bubbles come out.

I'll have these outside,

so you can play around with some of these demos

if you'd like, afterwards.


Basically, by controlling the genes,

you can control multiple materials to improve your device performance.

The last example are solar cells.

You can also do this with solar cells.

We've been able to engineer viruses to pick up carbon nanotubes

and then grow titanium dioxide around them,

and use it as a way of getting electrons through the device.

And what we've found is through genetic engineering,

we can actually increase the efficiencies of these solar cells

to record numbers

for these types of dye-sensitized easily water based solar cell systems.

And I brought one of those as well,

that you can play around with outside afterward.

So this is a virus-based solar cell.

Through evolution and selection,

we took it from an eight percent efficiency solar cell

to an 11 percent efficiency solar cell.

So I hope that I've convinced you

that there's a lot of great, interesting things to be learned

about how nature makes materials,

and about taking it the next step,

to see if you can force or take advantage of how nature makes materials,

to make things that nature hasn't yet dreamed of making.

Thank you.


The Description of Engineering biology to make materials for energy devices | Angela Belcher | TEDxCaltech