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Practice English Speaking&Listening with: Medical Miracles with Ambien - Hamilton's Pharmacopeia

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[ badly slurred] This is Tom and it's the 20th of August

around 10 after 12:00 AM

And this is me

reading this

[badly slurred] Belonging

[badly slurred] to the Y

[badly slurred] Strengthens Communities

and

Two hours later, this is how I talk now

Notice how my mouth seems to be moving a whole lot less. There's no straining.There's no

spasming big change from the"[goofy voice] "oh I can't talk man"

man

So there's something in the ingredients in ambien that

allow me to speak and relax and

You know I can actually talk like a normal person which is great

Ambien is a drug with many faces and not all of them are sleeping

best known for treating Insomnia

causing bouts of uncontrollable nocturnal binge eating and endowing Tiger woods with enhanced sexual abilities

Ambient has another property one that may very well change medical history by normalizing

neurological functioning and damage to brains

in

1996

24 Year-Old Louie V owen was struck by a truck resulting in an injury that left him in a persistent vegetative state

then in

1999 Louie's mother decided to feed her unconscious son a crushed ambien tablet through a straw to reduce

Involuntary muscle spasms in his arms

to her amazement

Louis spontaneously regained consciousness opening his eyes and speaking for the first time in 3 years and

So I decided to visit Louie in South Africa and learn more about the ambient effect

I met with Dr.. Walley Nel who has known Louis since he was a child and saw Louie through his zolpidem metamorphosis

is me

Louie VC, Saw

Left man. Hahaha look on this!

[foreign language] Do you know that you?

Were the first person in the whole world

That took this soul knocks

Yes, what still work? Oh?

Yes, oh yes, it's still working that was the picture how he looked before his accident

Louie was 25 years old and he was working at the Far Eastern hospital as

Switchboard operator, and he borrowed a bicycle from one of the frames thing and that knotted about how post 11

He somebody was outside market, and they were calling me there was an accident a bicycle accident

so they took me through to the ICU and he was lying there

But his head was twice as big as it used to be cause he was brain damaged. It was terrible you know for

For a mom, to see your son like that that's bad.

New Year's in the solid coma he never said one single word nothing

He swallowed the tablet and we were staying here myself and my husband and I think it was after 20 minutes I

Just heard things he didn't say anything he just did the- did the "mmm" this

Like in the past but I said

I said sweetheart something and he said "Bareyne, it's nothing"

and after about 40 minutes

He's asked for life. You know love stars

It was like twinkling and I said "Louis can you hear me?" then all of a sudden he says "yes"

He says yes, hello, Mommy

andI couldn't believe and I couldn't I just cried and I phoned up to Wally and I've heard my family

said Louie can talk!

She told me the story. I said it's totally impossible this doesn't happen these things in my time

The Brain is dead it's dead.

So I came out on the Sunday. We gave him the tablet and I went to stand there me and the family was standing down the bed

I saw also the twinkle in the eye, then you started with all your monsters then! hMM

He is a rehabilitation

Louie had these three tablets a day

He's on half twice a day now his Iq

10 o'clock before he gets his tablet is 70 and

After the tablet two hours after the half his IQ goes up to 90

what other sorts of brain injuries could be treated with Ambien what we have treated [and] what we are treating as multiple sclerosis a

Dementia

Alzheimer's

cerebral palsy near drownings

We've got the problem. We've got the answer

But we haven't got the in-between

We didn't know we didn't know where to start or how to start until the Ralphie is the big fun be honest on

That one there on the explanation part on the more scientific ornament

In 1999 Ralph Klaus stumbled upon an article about the miraculous awakening of Louis Vienne and decided he wanted to study the effect

further by imaging changes in cerebral Perfusion before and after ambien

What happened in Louis' Brian

Was that the way these big areas that weren't

functioning at all were kind of dark areas and then after zolpidem

These regions all normalized so like a day/night

difference

This this is Louis' brain his original state before was operative and you can see this large

decreased uptake in the Parietal region which

Normalizes after zolpidem and see with error is there

[three] it's about forty percent of normal

comes to

A hundred percent after zolpidem. So you have these two phenomena. You have the excited toxic effect

Which is the same time destabilizing the micro environment say I was almost is

suicide cells that offer themselves for the greater good and you

have the other cells which are influenced by the GABA which don't

regulate and survive. The exact

Biochemical mechanism of ambience therapeutic effect in Brain injury has yet to be identified

But Dr.

Klaus theorizes the GABA-A ion channel Undergoes an epigenetic change after brain trauma

Causing an unregulated influx of chloride ions that suppress neuronal activity so you have really

two different

Gaba-a receptors here you've got the normal gaba receptors which you know it induces the sort of sleepy change

then you have the

abnormal receptors

Which has gone through all these these phrases after brain injury is not the same as this original receptor anymore

It is a receptor.which is super sensitive and

Zolpidem through distorting this receptor

normalizes it again

and when that happens

Then the brain becomes less suppressed obviously and you see these

changes on the brain spect scan or metabolic [tells] and you see the changes, Clinically, so

Something works anywhere in this in this in this spectrum, basically

Because every way in the spectrum you have you have this this part that is

Damaged, dead if you like, all

non-Reversible injury if you like

And you've got this parallel area of dormancy

This is Jonathan pool. He's a bank manager here in Guildford actually and

He had a stroke

And after the stroke he had problems understanding people music suffers from auditory diagnosis her so he hear sounds and hears words

But he doesn't know what they mean

Dr.. Klaus, and I went to meet Jonathan Poole the banker who lost his numbers a

Sudden stroke at the age of 56 left pool with a lesion in his left temporal lobe

That interfered with his ability to read and understand language

Dr.. Klaus Prescribed pool Zolpidem and I wanted to see the effects firsthand

See I can hear what you're saying very well

But if Klaus talked to me, I would not have half of what saying

Because this this ear is

Doing something funny

inside the brain

So so when I talk to it like that, I talk quite well

But right here from this word my words will come very short the [ceiling] [oh]

Interesting and if you see Dr.. Klau's lips while he speaks are you then able to interpret the words?

Most of it, but it's a new word

like names

numbers People

Don't hear and this is written down in front of me that I might have a chance to say it

See took me

nearly

Six months to hear my wife's name

which is

Sue or Susan but it was someone on the phone and just give a name of sue

It's all it guh

That means no name to me at all

It's been very much more easy since he's been under zolpidem. I wouldn't let anyone take him off it

I really wouldn't because it makes life so much easier for us all

But before his stroke Jonathan was very articulate. It was very good with figures [and] things like that

Since his stroke although he can obviously now speak properly. He does still have problems with words

He very bad with numbers particularly over the telephone so quite often if he gives me a message over the phone

I know I have to check it first because it's quite possible. He's got the words wrong numbers wrong

Could we test the effect Dr.. Klaus would you?

Write down a few numbers

Just sort of more of this complex numbers if it's a give you five numbers right and then you

You say them once I say them. I said yes, you know your videos often an hour later. We do the sentence. Yes now

He will see something

Possible, okay you ready. Yes

583

153

613

377 Something some 291

250..250..251

830

th..

three and

I've lost it. I had I think I think I had three but I've lost I didn't hear it quickly enough

So that one I've lost that one yeah

991

171 okay, we asked you five questions and five were wrong. Yeah

[Laughing] Let's get your favorite item right oh

Even though Jonathan Poole had already taken one ten milligram ambien that morning the effects had diminished by the time we arrived

So he asked him to take a second allowed 60 minutes for the drug to Reach optimal

Concentrations and tested him again to see if his understanding of numbers had improved

641

6-4-1

198 1-9-8

472 4-7-2

Seeing the positive effects of Ambien on pool and Louie was extremely impressive

But there was still the matter of Thomas Rowe a voice-over artist. Who's one of the most dramatic

responders to the ambient effect "that was fun!"

In 2009 Rowe played a tragic visit to the dentist one that left him without a wisdom tooth and

without the ability to speak or

Rowe's career was ruined and he was forced into retirement at the age of 52

One night. He stayed awake on Ambien to find his voice

Had returned this is how I talk now [and] so I traveled to Orlando, Florida to meet Tom at his former studio

Sunspots I

Spent an hour years here. I was the voice of

The circuit city when they were in business for six years I did a lot of Nissan, uh..

"It all ends tomorrow!"

That kind of stuff. When I hear myself or feel myself speak it's hard I sit, it's hard

to believe

Ya know? Oh, it was like a country song I lost my career, and then my dog died and

what can I do other than

if there was a job for someone with a speech disorder

It's not so much. I I want to go back

behind the Mic again

But I would like to speak without pain, 'cause it really hurts.

For someone that hasn't experienced anything like this could you describe it feels like muscularly?

if you took your bottom lip and

Pulled it hard maybe as hard as you could out

and then took your neck and grab that and pull it back

The forehead and pulled up

And your cheeks and pull back

And I feel everything thing

Turlock

only

Drug the work is handy

in order to test ambience therapeutic effect [I]

Asked Tom to promote a Chevy spring event the [GMS]

Every spring of that. I'm more patient $8,000 off or next Tahoe

[lure], I can hear me

And the inside me

Breathing that I know the rhythm I know the sound

Drives me..

unlike many brain Trauma patients who don't experience ambience typical hypnotic effect tommrow started to become

inebriated

In a world of giant monkeys only one man will stand above the apes

tonight on WGN and

Will need to arm them with the skills the knowledge and the confidence they need to be victorious

Yeah, that's pretty good. Yeah. He's funny. Can't deny them in his

It's working yes, it's not there yet

it's working while

General Grant was busy with his horses there was something going on

Deeper in the South...

the sun had set and although Tom had to fight a strong urge [to] sleep his voice was back and

Couldn't be stopped. It's Mardi gras at Universal studios. Who are you gonna? Love it [cher] we're gonna have a big [time]

Yeah

that's no different than what was done when I was there and

now with the ambien in full effect

[I] once more asked Tom to promote a Chevy spring event

It's the [gene] Messer Chevy spring event and we're taking

8,000 dollars off your next tahoe. That's right get a Brand-new 2010 Chevy tahoe at Jean Messer Chevrolet, and we'll take

$8,000 off MsRP. It's time for our new Chevy Tahoe from Jean Messer Chevrolet

Wow, wow, it feels like being

Alive when I do that

Don't do that cause [ooh], [hahaha]

What started out as a serendipitous discovery may now represent one of the most important interventions for brain Trauma?

with time and medical research who knows what the future may hold

We try to push along this research on zolpidem all the research that you do is actually just

art of interest in Goodwill of

Of people who are trying to find out what's going on?

It's just scientific curiosity really these

Insomnia tracks are not optimized for pattern of brain damage and therefore there is a lot of money to be made

but if people develop this and optimize it specifically for

for people with brain damage

Now for myself getting on it's it's such a wonderful thing. [how] can we leave [it]? I don't think it's fair to any

Anybody or any population or any race or anything to say leave it with what we've gone [through] now

you

The Description of Medical Miracles with Ambien - Hamilton's Pharmacopeia