hi everyone we're back again with another antibiotic in our pharmacology
series and today we're gonna be speaking about the cephalosporins
so before we get started we'll start with our medical disclaimer you can
actually pause the video and read it we usually put the disclaimer up because as
nurses and nurses to be safety safety is always a priority so cephalosporins
our antibiotics that treat gram-negative and gram-positive bacteria they're
considered to be broad-spectrum antibiotics and the way they work is
that they bind to the bacterial cell wall and it causes the cell that has the
bacteria in it to die because cephalosporins
are broad-spectrum they are used to treat a variety of different infections
so we have pneumonia urinary tract infection is used for tonsillitis it's
used for gonorrhea it's used to treat a broad array of illnesses infections so
one of the easiest way to identify a cephalosporin is to actually look at the
prefix of the name and you would see with cephalosporines they all start
with CEF CEF or Cee pH so you have Cefdinir cefalexin ceftriaxone cefazolin
so they have this CEF beginning to their name and
that's like a little memory tip for you because the cephalosporins starts with
the Ceph sound alright so cephalosporins can be given by the intravenous or IV
route intramuscular or IM route or oral and you will see that written as PO
because we still use some Latin terms in our everyday medical language and
PO simply means per OS by mouth the side-effects of cephalosporins I have
a little memory tip here for you and it's hairy Cephalosporins can
increase your blood sugar level allergic reactions one of the big testing area
with particularly Cephalosporins and another class of antibiotic that we will
discuss in another video it's allergic reactions and allergic
reactions can be mild or they can be severe and life-threatening right so it
can really great if it can go from something mild you know like a small
rash all the way up to laryngeal edema and close up your airway which is
definitely life-threatening insufficient platelets
did you know cephalosporin cause bone marrow suppression yes yes
so that leaves your clients at risk for blood clots okay and previously I told
you that cephalosporins can be given by the IV route it can be given
intravenously so you have to monitor your clients IV site right because you
know the client is at risk for blood clots renal problems cephalosporin is
excreted through the urine so it can be heavy it can be hard on your kidneys to
get rid of cephalosporins how do we monitor your patients renal function
what are the two labs that we would look at what labs what labs would we look
at to monitor your clients renal function yes yes you're right
the bun and creatinine yes those are two two labs that we would look at yellow
poop diarrhea a side effect of the cephalosporins our diarrhea and the
cephalosporins are known for causing a special type of diarrhea called c-diff
diarrhea Clostridium difficile diarrhea so we have to
monitor our patience for changes in their bowel movements and diarrhea if
they're having diarrhea something that I need to bring your attention to and this
is just it this is not unique to cephalosporins this is for all
medication GI disturbances any medication that is taken by the oral
route because it has to go through your gastrointestinal system your patient
will experience some form of GI disturbance and the GI t service can be
nausea vomiting it can be diarrhea it can be anorexia there are some
medications that actually leave like a metallic taste in your mouth you have a
funny taste in your mouth there's some diarrhea that I mean some medications
that cause constipation so any medication that you take by the oral
route has the ability to cause some sort of GI disturbance and that's a good
memory tip for you to remember for all oral antibiotics some special
considerations with cephalosporins before you start any antibiotic
treatment the doctor is going to order a culture and sensitivity tests for your
clients and we do this test before your client starts their anti biotic therapy
so usually they would order the test and the doctor typically would have you
start a broad-spectrum antibiotic before the results come back and we do this
because we want to get your client starting to feel better we want to get
this bacteria that's May the person sick out of them and then
after they get the results from the culture and sensitivity the doctor may
actually change from a broad-spectrum antibiotic to a more specific antibiotic
depending on the bacteria that shows up in the culture and sensitivity we need
to ask our client about allergy history even if there's allergy history in the
chart or you might have asked the client before maybe earlier in your shift you
will go back and you will double-check allergy history and the reason why we do
that is because there is a cross allergy between cephalosporins
and penicillin so we really want to check with our clients regarding any
history of penicillin allergy because if the person has an allergy to penicillin
they're also going to have an allergy to cephalosporins
because you know of the cross allergy between them right and a good memory tip
for that is that we don't give the sailings the steps we don't get the sets
with the ceilings okay so that's just a little memory tip so now let's say you
give your patient on a dose of their cephalosporin and then they're having an
allergic reaction what would you do do you know what to do well what you would
do is you would hold and so you would stop and hold the medication right and
then the next thing that you're gonna do you're gonna assess your a patient to
see exactly what they're allergic reaction is right so your assessment you
know may involve you inspecting them you may have to auscultate the lungs because
you want to know if this is affecting the person's own respiratory status you
have to your client is the is declining and then
if they're having a really severe allergic reaction the antidote that we
are going to use is epinephrine right the antidote for the allergic reaction
you know is epinephrine right
cephalosporins are one of the classes of antibiotics
that should be taken with food because if you take your cephalosporin on an
empty stomach is going to decrease the effectiveness of the medication so your
client would not experience the maximum benefits of the medication if they take
it on an empty stomach we do not want our clients consuming alcohol while
they're taking cephalosporins because it causes a disulfiram like reaction in the
client and that is not a very pleasant feeling they'll have you know it may
present us headache muscle cramps dizziness vomiting so we also want to
question our clients also about their alcohol consumption because let's say
your client came through the emergency room and they're intoxicated we would
want to make sure that we're not gonna give them a cephalosporin because we're
gonna get this die so from like reaction and the doctor would have to order a
different class of medication for your clients we do not want to give
cephalosporins to clients with renal impairment because cephalosporins
is excreted through our urine so if the person has kidneys that are impaired we
don't want to add a cephalo Assefa cephalosporin
to this because it's going to make their kidney function even worse so we would
not give it to someone that has problems with their kidneys we do not want to
administer cephalosporin together with calcium containing products because this
can also decrease the effectiveness of the medication we want to teach our
client to take the entire course of their medication regimen even if they
are feeling better and the reason we would want to do this is because the
medication killed off some of the bacteria but definitely not all so what
happens the bacteria gets smarter than the medication and the bacteria becomes
resistant and their medication antibiotic does not work anymore right
so then your client will then have to get a different treatment a different
class of antibiotics to treat the infection that they have and we
definitely don't want that we have to teach our clients especially our
diabetic clients that suffering can cause hyperglycemia and false urine
glucose tests so we want to let our diabetic client know that they may need
to monitor their blood sugar a little more frequent while they're on their
course of cephalosporins we also want to teach clients that
cephalosporins can cause false positive opioid tests so that way they don't get
alarmed if something like that is to occur we also want to teach our client
to watch out for the following signs and symptoms there's like furry overgrowth
on the tone diarrhea that has caused or bloody if they have in vaginal itching
because all of those are signs of a super infection and we don't want our
clients at home trying to treat this super infection that may be developing
while they're on their current antibiotics remember earlier in the
previous slide I told you that cephalosporin caused c-diff diarrhea and
your client would have to get an additional treatment if they develop
this form of diarrhea so that's all our notes that we have for cephalosporins
we'll be back with another class of antibiotics in the series and until then
take care be well good bye