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Practice English Speaking&Listening with: In vivo Patient-Derived Xenograft (PDX) Models for Oncology Research Studies

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A PDX model stands for patient-derived xenograft.

That means in the oncology space that

patient tissue, normally tumor,

is transplanted from a human patient

into a mouse to maintain as a model.

In recent years there were multiple efforts

to establish and characterize large PDX collections.

Although these models are available

for a number of decades since the 1980s,

their advantages have become more and more important

for drug development and tumor biology research.

The main advantages of PDX models

are that they maintain their genetic heterogeneity

as well as the histological makeup of the patient

and preserve them over the passages.

This gives them the possibility to cover

all different histotypes from a specific disease.

Charles River offers a great PDX collection

covering more than 500 different models,

including all different entities like the broad models,

like non-small cell lung cancer, breast cancer,

or colon cancer,

but as well, tumor models with a high medical need

like ovarian cancer, acute myeloid leukemia,

non-Hodgkin lymphoma or prostate cancer.

The PDX models in the Charles River compendium

are characterized with molecular techniques

like whole-exome sequencing and RNA-seq.

We also have patient metadata available

as well as histology and immunohistochemistry data

and sensitivity toward standard of care treatments.

With the advent of new modalities,

like for example, immuno-oncology,

we tried to enhance our PDX models

by analyzing them also in a humanized setting.

For example, we analyzed the rates

of tumor-infiltrating lymphocytes,

as well as sensitivity toward checkpoint inhibitors.

PDX models are an important part of the preclinical toolbox

because they are complementary to the gold standard models

like cell line graft models,

syngeneic, or genetic modified mouse models.

The Description of In vivo Patient-Derived Xenograft (PDX) Models for Oncology Research Studies