Meaning: “Hello, how are you?”

No matter what you learned in English lessons, do not greet a friend or acquaintance with, “How do you do?” What’s up? or the even more informal ‘sup? mean the same thing without making you sound like you should be doffing a top hat. In more formal situations, it’s better to say, “Nice to meet you” or “Nice to see you.”

The beauty of What’s up? is that it is not really a question in need of an answer. Just like the French “ça va?” you can respond to “What’s up?” with… you guessed it: “What’s up?”!

We know you’re thinking it, so here’s the beer commercial that made the phrase world famous.